RAD 140 (Testolone): Benefits, Side Effects, Dosage, Safety, & More

RAD 140 is a SARM that is becoming very well-known for its incredibly potent muscle-building properties and fat-loss potential.

With qualities like these, it’s no surprise that this selective androgen receptor modulator is rapidly becoming a tool of choice with athletes and hypertrophy enthusiasts.

The demand for performance-boosting supplements has never been greater, and RAD 140 is rumored to be able to deliver incredible results with fewer harsh side effects.

In this comprehensive deep-dive, we’ll explore RAD 140 and how it works, along with the potential benefits, guidelines for usage, and the potential health concerns associated with it.

Once we’ve gone over the details of RAD 140, we’ll also take a look at where consumers can find it for those who want to integrate it into their supplement regimen.

We’re going to cover it all, and by the end you should have a comprehensive understanding of RAD 140, from its mechanism of action to the potential risks of use, allowing you to make a much more informed decision on whether or not it fits your needs.

What is RAD 140?

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Testolone, or RAD 140, is a selective androgen receptor modulator that was first created to help manage wasting diseases and osteoporosis.

Unlike conventional anabolic steroids, SARMs are designed to specifically target androgen receptors located in bone tissue and muscle tissue, without affecting other organs.

The ability to avoid impacting or damaging other organs is one of the biggest differences between RAD 140 and anabolic steroids.

RAD 140 is extremely potent, and in mimicking the effects of the main male sex hormone, testosterone.¹

By mimicking testosterone, RAD 140 can promote radically increased muscle growth, and boost physical performance.

As a SARM, RAD 140 binds only to androgen receptors in muscle and bone, which stimulates anabolic activity.²

This anabolic activity results in muscle hypertrophy and increased bone density.³

The selective action of RAD 140 not only boosts muscle growth but also helps keep the lean muscle mass already present when the body enters a cutting phase.

For individuals who cycle between bulking and cutting phases, this makes RAD 140 a very versatile tool.

First developed by Radius Health, RAD 140 has been the focus of several preclinical studies to assess the compound’s safety and efficacy.⁴

These initial studies have shown some relatively promising results, with animal models showing substantial muscle gains alongside improved bone health.

Even though human clinical trials are still limited, the existing body of research and anecdotal evidence strongly suggest that RAD 140 is highly effective in helping to improve general body composition.

With such a highly targeted approach, and resulting powerful effects that mimic anabolic steroids, RAD 140 has quickly become a favorite SARM.

It’s not only become popular with general fitness enthusiasts but with professional bodybuilders looking for a safer alternative to anabolics.

Overall, the ability to create gains in muscle mass, power, and endurance, combined with a favorable safety profile, makes RAD 140 a leading performance compound.

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RAD 140 Health Benefits

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RAD 140 is purported to offer a range of benefits to general health, specifically for individuals hoping to fine-tune their body composition.

Its action of selectively targeting the androgen receptors makes it one of the most powerful tools for fat loss, muscle growth, and general physical enhancement.

The primary benefit of RAD 140 is its ability to build substantial amounts of lean muscle mass.

By selectively binding with androgen receptors, it stimulates general anabolic activity, which leads to elevated protein synthesis and muscle growth.

Anecdotal reports from users often report significant muscle growth in just the first few weeks after use begins.

This effect by itself would make RAD 140 one of the most popular SARMs on the market, but that’s not all it can do.

In addition to the substantial reported muscle-building, RAD 140 also helps burn more fat.

By boosting metabolic activity, it helps the body burn more fat, and to burn it more efficiently.

The dual effect of growing the lean muscle tissue while also reducing the body’s fat stores makes RAD 140 unbelievably useful during challenging cutting phases.

Users can maintain their existing level of lean mass, while also shedding stored fat, multiplying the visual effect of a more toned, defined, physique.

The physical fat-loss and hypertrophy effects are just the beginning, RAD 140 has been shown to have useful neuroprotective effects as well.

Early research indicates that it may be able to help protect cellular structures in the brain from damage, and may help support healthy cognition.⁵

This can be priceless news to those individuals who may be facing age-related or other neurodegenerative conditions.

By mimicking the effects of biological testosterone in the brain, RAD 140 helps retain a level of neural health and basic function, improving overall well-being.

RAD 140 also plays an important role in the improvement of bone density.

When RAD 140 targets the androgen receptors in bone tissue, it promotes the formation of new bone tissue and lowers the ongoing risk of bone fractures.

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These benefits can make it a very attractive compound for individuals living with osteoporosis, or anyone looking to enhance bone strength.

Healthy levels of bone activity and density are critical for general physical performance and longevity, specifically for older adults and athletes.

Another important benefit of RAD 140 is the impact it can have on an individual’s endurance and post-workout recovery.

Anecdotal evidence from users states many experience enhanced stamina alongside reduced fatigue during workouts.

Lower levels of fatigue and increased stamina directly translate into longer, and more intense workouts or training sessions.

Additionally, RAD 140 helps the body recover more quickly following exertion, reducing muscle soreness as well as downtime.

Being able to tire slower and recover quicker contributes significantly to more rapid gains in physical fitness as well as in measured performance.

Overall, the potent effects on lean muscle growth, fat loss, neuroprotection, bone health, and endurance are sure to make it one of the most valuable, versatile additions to your fitness regimen.

How To Use RAD 140

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Some of the most important information to have before starting a SARM is proper usage information.

To reach optimal results, individuals using or considering using RAD 140 should know the risks, proper dosage, cycles, and administration methods.

For most beginners, the typical starting dose of RAD 140 will be between 10 mg and 20 mg per day.

It’s always advisable to start with as low of a dose as possible, to assess the body’s response and general tolerance, then increase gradually.

More experienced or advanced users may potentially take up to 30 mg per day, but taking more than that is not recommended and may lead to side effects.

The typical RAD 140 cycle will last from 8 to 12 weeks, after which there should be a break to allow the body to recover and lose tolerance.

The break should be at least as long as the cycle, if not longer, so that the body’s natural hormonal balance can be found again, avoiding possible negative side effects.

RAD 140 is usually administered orally, and is available in liquid form or as capsules, with no significant differences between the two for the user.

The liquid form can be measured and directly consumed, though many users find the pre-measured capsules to be more convenient.

To ensure the body has consistent levels of RAD 140, it’s ideal to take it at the same time each day.

Some users take their dose in the morning, while others will take it before their daily workout to boost immediate performance.

No matter what time you take it, be sure to stay consistent in that dosage schedule to get the ideal results.

To get the most out of your RAD 140 cycles, you should also strive to maintain a balanced diet accompanied by regular exercise.

The ideal diet to support muscle growth and subsequent recovery will be rich in protein.

Also, incorporating strength training and cardio workouts into your typical routine can help magnify the benefits of RAD 140.

It’s critical to stay hydrated and get plenty of rest, as with any fitness regimen, particularly when boosting performance with supplements.

Be on the lookout for any changes in mood, energy levels, or physical appearance to monitor and be aware of your body’s response to RAD 140.

Where To Buy

For individuals who feel RAD 140 may be a good fit, it’s crucial to find a reputable source who deals both in high-quality product, and safety.

With peptides, SARMs, and other research chemicals being incredibly popular right now, tons of suppliers just don’t put their customers first.

Chemyo is one of the leading sources and most trustworthy suppliers of RAD 140.

They test each batch of RAD 140 to ensure it meets the pinnacle of purity and industry standards, with the results posted right on their website.

They are dedicated to transparency, customer education and safety, and industry-leading customer service.

Visit their official page on RAD 140 here to learn more.

RAD 140 Health Concerns

Even though RAD 140 has some incredible benefits, it also comes with some potential side effects that any user should be aware of ahead of time.

If used for too long without a cycle break, RAD 140 has the potential to suppress natural testosterone production.⁶

There is also a chance of liver toxicity with any SARMs, so it’s recommended that all users have regular liver function tests.^{7 8}

RAD 140 also impacts cholesterol and can cause the balance of LDL and HDL to shift toward LDL.

Frequently Asked Questions

What is the best dosage for RAD 140?

The best dosage for RAD 140 will vary but beginners will tend to start somewhere between 10 mg/day and 20 mg/day, and experienced users may take up to 30 mg/day, but more than that can be dangerous.

Can women use RAD 140 safely?

Women can use RAD 140, but they should do so with caution, and only start at 5 mg per day while monitoring the body’s response. It's even been shown in some limited clinical studies to have some antitumor activity in women with breast cancer.⁹

How long does RAD 140 stay in your system?

The half-life of RAD 140 can be as long as 20 hours, so it can take several weeks for RAD 140 to be completely cleared from the system.

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Summary

RAD 140 has substantial benefits for anyone looking for a simple way to boost muscle growth, increase strength, and enhance their overall physical performance.

While it offers robust benefits, the selective action on androgen receptors helps limit the scope of what it affects, making it much safer than steroids.

If RAD 140 sounds like a good fit for your fitness journey or research needs, Chemyo is a highly recommended source, thanks in no small part to its QA, transparency, and excellent support for all customers.

From the seasoned athlete to the dedicated fitness enthusiast, RAD 140 has the potential to be an incredibly valuable addition to your toolkit.

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References

1. Jayaraman A, Christensen A, Moser VA, et al. Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats. Endocrinology. 2014;155(4):1398-1406. doi:10.1210/en.2013-1725

2. Christiansen AR, Lipshultz LI, Hotaling JM, Pastuszak AW. Selective androgen receptor modulators: the future of androgen therapy?. Transl Androl Urol. 2020;9(Suppl 2):S135-S148. doi:10.21037/tau.2019.11.02

3. Vignali JD, Pak KC, Beverley HR, et al. Systematic Review of Safety of Selective Androgen Receptor Modulators in Healthy Adults: Implications for Recreational Users. J Xenobiot. 2023;13(2):218-236. Published 2023 May 10. doi:10.3390/jox13020017

4. National Center for Biotechnology Information. PubChem Compound Summary for CID 44200882, Testolone. https://pubchem.ncbi.nlm.nih.gov/compound/Testolone. Accessed June 27, 2024.

5. Wnuk A, Kajta M. Steroid and Xenobiotic Receptor Signalling in Apoptosis and Autophagy of the Nervous System. Int J Mol Sci. 2017;18(11):2394. Published 2017 Nov 11. doi:10.3390/ijms18112394

6. Miller CP, Shomali M, Lyttle CR, et al. Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140. ACS Med Chem Lett. 2010;2(2):124-129. Published 2010 Dec 2. doi:10.1021/ml1002508

7. Leung K, Yaramada P, Goyal P, Cai CX, Thung I, Hammami MB. RAD-140 Drug-Induced Liver Injury. Ochsner J. 2022;22(4):361-365. doi:10.31486/toj.22.0005

8. Mohamed WT, Jahagirdar V, Fatima I, et al. Selective Androgen Receptor Modulators (SARMs)-Induced Liver Injury: A Case Report and Review of Literature. Cureus. 2023;15(2):e35094. Published 2023 Feb 17. doi:10.7759/cureus.35094

9. LoRusso P, Hamilton E, Ma C, et al. A First-in-Human Phase 1 Study of a Novel Selective Androgen Receptor Modulator (SARM), RAD140, in ER+/HER2- Metastatic Breast Cancer. Clin Breast Cancer. 2022;22(1):67-77. doi:10.1016/j.clbc.2021.08.003

Disclaimer: The above is a contributor post, the views expressed are those of the contributor and do not represent the stand and views of Outlook Editorial.