Have you been looking for the best PCT for SARMS, but have no idea where to begin?

Post cycle therapy is a critical stage for men who have completed a cycle of SARMs, or anabolic steroids.

PCT compounds are needed to help restore the body’s natural hormone balance, and testosterone in particular.

This is because testosterone is one of the most frequently suppressed hormones during a cycle of SARMs.

7 Best PCT For SARMS

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In this article, we’re going to explore some of the most effective supplements designed specifically to help men recover while maintaining their results.

They include (in no particular order):

• Clomiphene

• Nolvadex

• Enclomiphene

• Anastrozole

• Letrozole

• Raloxifene

• Arimistane

By getting a clear understanding of the specific role of each supplement, you’ll be able to make more informed decisions about which compounds are right for your PCT.

#1. Clomiphene PCT For SARMS

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Clomiphene, more commonly known as Clomid, is one of the foundational components of post-cycle therapy for men.

This is due to its incredible effectiveness in restoring natural testosterone levels following a cycle of SARM use.

Clomiphene is a SERM, or a selective estrogen receptor modulator, which means it works by binding to estrogen receptors and tricking them into thinking estrogen levels are low.^{1 2}

This results in a chemical cascade leading to the release of gonadotropin-releasing hormone, GnRH, which then leads to an increase in luteinizing hormone and follicle-stimulating hormone.

LH and FSH are both critical for stimulating the testes to produce more testosterone and helping to restore natural hormonal balance while maintaining muscle gains.

Clomiphene is particularly effective at minimizing post-cycle crashes, where testosterone levels plummet, leaving you feeling high levels of fatigue, depression, libido loss, and muscle wasting.

While Clomiphene is seen as generally well-tolerated, it can definitely have some side effects.³

#2. Nolvadex

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Nolvadex, also known generically as Tamoxifen, is another important component of post-cycle therapy due to its efficacy in stopping estrogen-related side effects.⁴

It also helps restore the body’s natural testosterone production.

As a selective estrogen receptor modulator, Nolvadex attaches to estrogen receptors, specifically in breast tissue, thereby blocking the estrogen that leads to gynecomastia.⁵

With gynecomastia being one of the primary concerns with men completing a SARM cycle, this can make Tamoxifen an ideal agent to prevent it.

The mechanism of action makes Nolvadex especially effective in preventing the development of male breast tissue, helping maintain their appearance and minimize discomfort.⁶

Other than its role in blocking estrogen, it also triggers the pituitary gland to secrete LH and FSH.

These two hormones help jump-start the natural testosterone production, which is typically suppressed during a SARM cycle or while using anabolic steroids.

With the promotion of endogenous testosterone production, Tamoxifen helps preserve muscle mass, keep energy levels up, and maintain libido, which can all be compromised when testosterone drops.

#3. EnclomiphenePCT For SARMS

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Enclomiphene is an incredibly effective SERM that plays an important role in many PCT regimens due to the tightly focused mechanism of action.

Enclomiphene is an isomer of Clomiphene, but it is designed specifically to block estrogen receptors in the hypothalamus.⁷

This action directly stimulates the release of luteinizing hormone and follicle-stimulating hormone from the pituitary.

These are essential components for helping to raise natural testosterone production rates after a full cycle of SARMs.

By helping encourage the production of endogenous testosterone, Enclomiphene helps bring back a natural hormonal balance, while protecting muscle mass and supporting general recovery.

One of the key advantages of Enclomiphene over Clomiphene is its reduced risk of estrogenic side effects.

Unlike Clomiphene, which is a mixture of an anti-estrogenic isomer and an isomer with potential estrogenic effects, Enclomiphene is solely composed of the anti-estrogenic isomer.

This means Enclomiphene operates with a more highly targeted approach and minimizes the risks of side effects like mood swings, hot flashes, or visual disturbances.⁸

Another relatively significant benefit of Enclomiphene is that it helps maintain sperm count while boosting testosterone levels.

This can be particularly important for men concerned about fertility during their PCT regimen.

#4. Anastrozole

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Anastrozole, or sometimes Arimidex, is another powerful aromatase inhibitor that can be integrated into a post-cycle therapy regimen.⁹

At a high level, Anastrozole works by preventing the conversion of testosterone into estrogen, in a process known as aromatization.

This process can lead to dramatically elevated estrogen levels in the post-cycle period, which can result in gynecomastia, mood swings, and water retention.

Anastrozole works by inhibiting the aromatase enzyme, which leads to a reduction in estrogen levels, helping to maintain a hormonal balance needed for preserving muscle gains.¹⁰

It is particularly effective for men who are prone to high estrogen level rebounds following a cycle, or who have experienced estrogen-related side effects previously.

By helping to keep estrogen levels in check, Anastrozole helps stop gynecomastia while supporting testosterone stabilization.

This is an essential strategy for recovery and maintaining cycle results, as well as mitigating other estrogen-related issues.

While it is potent and highly effective, it’s critical to use it with caution and only with the guidance of a medical professional.

Over-suppressing natural estrogen can lead to some negative side effects, including joint pain, reduced bone density, and a lower libido.

#5. Letrozole PCT For SARMS

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Letrozole is another powerful aromatase inhibitor that can play a key part in the post-cycle therapy regimen for many men, particularly where estrogen control is the top priority.

Letrozole’s mechanism of action blocks the aromatase enzyme, which is needed for converting testosterone into estrogen.^{11 12}

This means it’s incredibly effective at lowering endogenous estrogen levels, which helps stave off unwanted side effects that result from surplus estrogen in the system.

These are the same side effects that men see following a testosterone crash, including increased breast tissue, retaining water, and gaining fat.

Due to the potency, Letrozole is most often used when there is a significant risk of post-cycle estrogen rebound, or when other aromatase inhibitors have proven to be insufficient.

One of the biggest benefits of using Letrozole is the ability to lower estrogen by dramatic amounts.

It is one of the most effective options for preventing gynecomastia in men who are prone to the condition.

This potent suppression can be important for maintaining the muscle gains and hormonal balance goals reached during a cycle.

#6. Raloxifene

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Raloxifene is another SERM that is of tremendous value in PCT for men who are concerned about gynecomastia, which can be common following SARM cycles.¹³

Raloxifene works by binding estrogen receptors in breast tissue specifically, making it more effective at blocking the effects of estrogen and lowering the risk of breast tissue development.¹⁴

For many men, this makes it a potent option for PCT when more targeted protection is needed.

Also, Raloxifene has been shown to have a positive impact on bone mineral density, which can be a substantial benefit during PCT, when the potential for bone density loss is greatest.

However, just like other SERMs, Raloxifene has the potential for negative side effects.

Some men may experience hot flashes, cramps in the legs specifically, and an elevated risk of blood clots.

#7. Arimistane

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Arimistane is a natural aromatase inhibitor that is a frequent component in post-cycle therapy regimens.¹⁵

It’s so common due to the ability to reduce estrogen levels while also supporting natural testosterone production.

As an aromatase inhibitor, Arimistane works by blocking the key enzyme needed for the conversion of testosterone into estrogen.

This helps maintain a more favorable hormonal balance after a cycle of SARMs or anabolic steroids.

This also makes it incredibly useful for men who need a powerful tool for minimizing side effects related to estrogen, like water retention or gynecomastia, while promoting natural testosterone recovery.

One of the biggest benefits of Arimistane is the milder profile compared to pharmaceutical-grade aromatase inhibitors, like Anastrozole or Letrozole.

This also makes it a suitable option for men who are looking for a gentler approach to estrogen control during their PCT regimen.

Armistane not only reduces estrogen levels but also boosts LH and FSH levels, which helps boost testosterone levels.

PCT For SARMS Summary

Post-cycle therapy is essential for any man completing a cycle of SARMs or other anabolics.

With artificial hormone regulation, PCT is critical for helping the body naturally rebalance hormones and protect against estrogen-related side effects.

Some of the leading PCT compounds like Clomiphene, Nolvadex, and Enclomiphene help boost testosterone levels.

Aromatase inhibitors like Anastrozole, Letrozole, and Arimistane help manage estrogen levels, which is important for preventing issues like gynecomastia.

For more targeted protection from estrogen’s effects on breast tissue, Raloxifene can be a valuable asset.

By knowing the roles and specific benefits of each of these compounds, you’ll be able to create the most effective PCT regimen for your needs.

With the right combination, you can ensure a smooth recovery and help maintain those gains you worked so hard for while keeping your overall well-being following a cycle.

Click Here Now to pick up any of these PCT’s from our top rated source.

References

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2. An KC. Selective Estrogen Receptor Modulators. Asian Spine J. 2016 Aug;10(4):787-91. doi: 10.4184/asj.2016.10.4.787. Epub 2016 Aug 16. PMID: 27559463; PMCID: PMC4995266.

3. Yilmaz S, Yilmaz Sezer N, G?nen? ?M, ?lhan SE, Yilmaz E. Safety of clomiphene citrate: a literature review. Cytotechnology. 2018 Apr;70(2):489-495. doi: 10.1007/s10616-017-0169-1. Epub 2017 Nov 20. PMID: 29159661; PMCID: PMC5851961.

4. Farrar MC, Jacobs TF. Tamoxifen. [Updated 2023 Apr 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-.

5. Williams MR, Gilson D, Marsh L, Morgan DA, Nicholson RI, Elston CW, Griffiths K, Blamey RW. The early results from a randomised study of radiotherapy versus Nolvadex (tamoxifen) as initial treatment for stage III breast cancer. Eur J Surg Oncol. 1988 Jun;14(3):235-40. PMID: 3371476.

6. Jordan VC. Tamoxifen as the first targeted long-term adjuvant therapy for breast cancer. Endocr Relat Cancer. 2014 May 6;21(3):R235-46. doi: 10.1530/ERC-14-0092. PMID: 24659478; PMCID: PMC4029058.

7. Thomas J, Suarez Arbelaez MC, Narasimman M, Weber AR, Blachman-Braun R, White JT, Ledesma B, Ghomeshi A, Jara-Palacios MA, Ramasamy R. Efficacy of Clomiphene Citrate Versus Enclomiphene Citrate for Male Infertility Treatment: A Retrospective Study. Cureus. 2023 Jul 6;15(7):e41476. doi: 10.7759/cureus.41476. PMID: 37546076; PMCID: PMC10404117.

8. Wiehle R, Cunningham GR, Pitteloud N, Wike J, Hsu K, Fontenot GK, Rosner M, Dwyer A, Podolski J. Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics. BJU Int. 2013 Jul 12;112(8):1188–200. doi: 10.1111/bju.12363. Epub ahead of print. PMID: 23875626; PMCID: PMC4155868.

9. Peters A, Tadi P. Aromatase Inhibitors. [Updated 2023 Jul 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-.

10. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Anastrozole. [Updated 2017 Jul 25].

11. Bhatnagar AS. The discovery and mechanism of action of letrozole. Breast Cancer Res Treat. 2007;105 Suppl 1(Suppl 1):7-17. doi: 10.1007/s10549-007-9696-3. Epub 2007 Oct 3. Erratum in: Breast Cancer Res Treat. 2008 Nov;112(2):385. PMID: 17912633; PMCID: PMC2001216.

12. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Letrozole. [Updated 2017 Jul 25].

13. National Center for Biotechnology Information. PubChem Compound Summary for CID 5035, Raloxifene.

14. Gizzo S, Saccardi C, Patrelli TS, Berretta R, Capobianco G, Di Gangi S, Vacilotto A, Bertocco A, Noventa M, Ancona E, D'Antona D, Nardelli GB. Update on raloxifene: mechanism of action, clinical efficacy, adverse effects, and contraindications. Obstet Gynecol Surv. 2013 Jun;68(6):467-81. doi: 10.1097/OGX.0b013e31828baef9. PMID: 23942473.

15. National Center for Biotechnology Information. PubChem Compound Summary for CID 169433792, Arimistane.

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