Israeli strikes pounded the Gaza Strip overnight and into Wednesday, with one attack ripping through a home where displaced people were sheltering in the isolated north. The strikes killed at least 33 people including children, Palestinian health officials said.

The Israel-Hamas war has no end in sight, even after Israel reached a ceasefire with Lebanon's Hezbollah militants and attention shifted to the overthrow of Syrian President Bashar Assad by insurgents. Both the current and incoming US administrations have said they hope to end the war in Gaza before the inauguration in January, but ceasefire talks have repeatedly stalled.

The strike on the home killed 19 people in the northern town of Beit Lahiya near the border with Israel, according to nearby Kamal Adwan Hospital, which received the bodies. Hospital records show that a family of eight was among those killed: four children, their parents and two grandparents.

The Israeli military said it targeted a Hamas militant in the vicinity of the hospital. It said reports about the number of casualties in the strike were inaccurate, without elaborating. The military says it tries to avoid harming civilians and accuses militants of hiding among them, putting their lives in danger.

The hospital said another strike near its entrance on Wednesday killed a woman and her two children.

The hospital director, Dr Hussam Abu Safiya, said Israeli drones struck nearby residential blocks overnight, causing explosions that sparked panic among the facility's more than 120 sick and wounded patients.

“We have received distress calls from neighbors and trapped people, but we're not able to leave the hospital because of the continued risk,” he said. “We are witnessing a massive loss of life, with many martyrs in the targeted areas.”

Another strike in the decades-old Nuseirat refugee camp in central Gaza killed at least seven people, according to the Awda Hospital. The dead included two children, their parents and three other relatives, it said. Later, the hospital said another attack hit the same camp, killing four people and injuring 16 more.

There was no immediate comment from the Israeli military on the other strikes.

In Lebanon, where near-daily Israeli attacks have continued despite the ceasefire, at least five people died Wednesday in Israeli strikes in the south, according to Lebanon's Health Ministry and state news agency.

Elsewhere in southern Lebanon, Israeli forces withdrew from a strategic town and handed it back to the Lebanese army in coordination with UN peacekeepers, the two militaries said. It appeared to be the first Israeli pullout from a Lebanese border town captured during the ground invasion.

In Syria, the Israeli military estimates it has destroyed 70 per cent to 80 per cent of Syrian military assets in recent days, according to an official speaking on condition of anonymity to discuss an intelligence assessment. The military has said it has carried out hundreds of airstrikes.

Militants in central Gaza fired four projectiles into Israel on Wednesday, two of which were intercepted, the military said. The other two fell in open areas, and there were no reports of casualties.

The military ordered the evacuation of a five-block area of the built-up Maghazi refugee camp in central Gaza, saying the rockets had been fired from there. The orders indicated that Israel would soon carry out strikes in the area.

The war began when Hamas-led militants stormed into Israel on October 7, 2023, killing some 1,200 people, mostly civilians, and abducting around 250 people, including children and older adults. Around 100 hostages are still inside Gaza, at least a third believed to be dead.

Israel's retaliatory offensive has killed over 44,000 Palestinians in Gaza, according to local health officials. They say women and children make up more than half the dead but do not distinguish between fighters and civilians in their count. Israel says it has killed over 17,000 militants, without providing evidence.

Thousands more Palestinians have gone missing during the war, some after encounters with Israeli troops.

Israel has been waging a renewed offensive against Hamas militants in Gaza's heavily destroyed north since early October. Troops have surrounded Beit Lahiya, Beit Hanoun and the urban Jabaliya refugee camp, allowing in almost no humanitarian aid and ordering tens of thousands to flee to nearby Gaza City.

Israeli officials have said the three communities are mostly deserted, but the United Nations humanitarian office said Tuesday it believes around 65,000 to 75,000 people are still there, with little access to food, water, electricity or health care. Experts have warned that the north may be experiencing famine.

Sigrid Kaag, the senior UN humanitarian and reconstruction coordinator for Gaza, told reporters on Tuesday that civilians trying to survive all across Gaza face an “utterly devastating situation.”

She pointed to the breakdown in law and order and looting that has left the UN and many aid organisations unable to deliver food and other humanitarian essentials to hundreds of thousands of Palestinians in need.

Kaag said she and other UN officials repeatedly ask Israel for access for convoys to northern Gaza and elsewhere, to allow in commercial goods, to reopen the Rafah crossing from Egypt in the south and to approve dual-use items.

The Israeli military says it allows in enough humanitarian aid and blames UN agencies for not distributing it, saying large amounts of aid have accumulated just inside Gaza's borders. UN officials say Israeli restrictions, the breakdown of law and order and ongoing fighting make it difficult to access the aid and distribute it, and have repeatedly called for a ceasefire.

The United States, Egypt and Qatar have mediated talks between Israel and Hamas for nearly a year, and diplomats say those efforts have recently gained momentum.

But Hamas has said it will not release the remaining hostages without an end to the war and a full withdrawal of Israeli troops. Israeli Prime Minister Benjamin Netanyahu has pledged to continue the war until Hamas is destroyed and all the hostages are returned and has said Israel will maintain a lasting military presence in some areas.